Dissociations between changes in myocardial cyclic adenosine monophosphate and contractility.

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Dissociations between changes in myocardial cyclic adenosine monophosphate and contractility.

The relationship between changes in the myocardial concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and cardiac contractility was studied in guinea pig and rat myocardium. When isolated perfused guinea pig heart were perfused with 10-5-M papaverine, a potent inhibitor of cyclic AMP phosphodiesterase activity, myocardial cyclic AMP concentration increased significantly from 1.7...

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Dissociations between Changes in Myocardial Cyclic Adenosine Monophosphate

The relationship between changes in the myocardial concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and cardiac contractility was studied in guinea pig and rat myocardium. When isolated perfused guinea pig hearts were perfused with 10"M papaverine, a potent inhibitor of cyclic AMP phosphodiesterase activity, myocardial cyclic AMP concentration increased significantly from 1.7 ...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1975

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.36.3.392