Dissociations between changes in myocardial cyclic adenosine monophosphate and contractility.
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منابع مشابه
Dissociations between changes in myocardial cyclic adenosine monophosphate and contractility.
The relationship between changes in the myocardial concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and cardiac contractility was studied in guinea pig and rat myocardium. When isolated perfused guinea pig heart were perfused with 10-5-M papaverine, a potent inhibitor of cyclic AMP phosphodiesterase activity, myocardial cyclic AMP concentration increased significantly from 1.7...
متن کاملDissociations between Changes in Myocardial Cyclic Adenosine Monophosphate
The relationship between changes in the myocardial concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) and cardiac contractility was studied in guinea pig and rat myocardium. When isolated perfused guinea pig hearts were perfused with 10"M papaverine, a potent inhibitor of cyclic AMP phosphodiesterase activity, myocardial cyclic AMP concentration increased significantly from 1.7 ...
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• This review examines critically the evidence bearing on the hypothesis that the positive inotropic effects of catecholamines are mediated by intracellular cyclic adenosine monophosphate (cyclic AMP). The review is selective in several respects. For example, it does not contain extensive discussions about the biochemical actions of cyclic AMP, the enzymes regulating its synthesis and degradati...
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Previous studies have suggested that the lnotropic effects of glucagon on the guinea pig heart, but not on the rat heart, could be dissociated from its effects on cyclic AMP formation. We compared the effects of glucagon on working rat and guinea pig hearts to reinvestigate this proposed dissociation. When administered to spontaneously beating preparations, glucagon produced •imilar increases h...
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The purpose of this study was to examine the mechanisms underlying adrenergic-cholinergic antagonism in ventricular myocardium. Myocardial contractility, cyclic adenosine monophosphate (AMP) levels, and cyclic guanosine monophosphate (GMP) levels were measure in isolated guinea pig ventricles after treatment with various inotropic agents given alone and simultaneously with acetylcholine. Acetyl...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1975
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.36.3.392